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Literature summary extracted from

  • Krause, S.; Hinderlich, S.; Amsili, S.; Horstkorte, R.; Wiendl, H.; Argov, Z.; Mitrani-Rosenbaum, S.; Lochmueller, H.
    Localization of UDP-GlcNAc 2-epimerase/ManAc kinase (GNE) in the Golgi complex and the nucleus of mammalian cells (2005), Exp. Cell Res., 304, 365-379.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.60 expressed in HeLa cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.60 Golgi apparatus associated Mus musculus 5794
-
2.7.1.60 Golgi apparatus associated Homo sapiens 5794
-
2.7.1.60 nucleus associated Mus musculus 5634
-
2.7.1.60 nucleus HeLa and muscle cells Homo sapiens 5634
-
5.1.3.14 Golgi apparatus
-
 Homo sapiens 5794
-
5.1.3.14 nucleus
-
 Homo sapiens 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.60 79000
-
 x * 79000, SDS-PAGE Mus musculus
2.7.1.60 79000
-
 x * 79000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.60 ATP + N-acyl-D-mannosamine Mus musculus key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, essential for early embryonic development ADP + N-acyl-D-mannosamine 6-phosphate
-
 ?
2.7.1.60 ATP + N-acyl-D-mannosamine Homo sapiens key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, essential for early embryonic development, enzyme involved in several genetic disorders such as sialuria, hereditary inclusion body myopathy, and Nonaka myopathy ADP + N-acyl-D-mannosamine 6-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.60 Homo sapiens
-
-
-
2.7.1.60 Mus musculus
-
-
-
5.1.3.14 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.60 cerebellum
-
 Mus musculus
-
2.7.1.60 cerebrum
-
 Mus musculus
-
2.7.1.60 embryonic stem cell homozygous or heterozygous gene knock-out cells Mus musculus
-
2.7.1.60 HEK-293 cell
-
 Homo sapiens
-
2.7.1.60 HeLa cell
-
 Homo sapiens
-
2.7.1.60 JURKAT cell
-
 Homo sapiens
-
2.7.1.60 K-562 cell
-
 Homo sapiens
-
2.7.1.60 liver
-
 Mus musculus
-
2.7.1.60 myoblast
-
 Homo sapiens
-
2.7.1.60 skeletal muscle
-
 Mus musculus
-
2.7.1.60 TE-671 cell
-
 Homo sapiens
-
2.7.1.60 testis
-
 Mus musculus
-
2.7.1.60 thymus
-
 Mus musculus
-
5.1.3.14 skeletal muscle developmentally regulated: high levels in immature myoblast but low levels in mature skeletal muscle Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.60 ATP + N-acyl-D-mannosamine
-
 Mus musculus ADP + N-acyl-D-mannosamine 6-phosphate
-
 ?
2.7.1.60 ATP + N-acyl-D-mannosamine
-
 Homo sapiens ADP + N-acyl-D-mannosamine 6-phosphate
-
 ?
2.7.1.60 ATP + N-acyl-D-mannosamine key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, essential for early embryonic development Mus musculus ADP + N-acyl-D-mannosamine 6-phosphate
-
 ?
2.7.1.60 ATP + N-acyl-D-mannosamine key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, essential for early embryonic development, enzyme involved in several genetic disorders such as sialuria, hereditary inclusion body myopathy, and Nonaka myopathy Homo sapiens ADP + N-acyl-D-mannosamine 6-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.60 ? x * 79000, SDS-PAGE Mus musculus
2.7.1.60 ? x * 79000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.1.60 UDP-GlcNAc 2-epimerase/ManNAc kinase
-
 Mus musculus
2.7.1.60 UDP-GlcNAc 2-epimerase/ManNAc kinase
-
 Homo sapiens
2.7.1.60 UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase two different enzyme activities combined in a single bifunctional enzyme Mus musculus
2.7.1.60 UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase two different enzyme activities combined in a single bifunctional enzyme Homo sapiens
5.1.3.14 GNE
-
 Homo sapiens
5.1.3.14 UDP-GlcNAc 2-epimerase/ManAc kinase bifunctional enzyme Homo sapiens
5.1.3.14 UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase
-
 Homo sapiens